But perhaps the number one choice for an herbal antihistamine is Stinging nettle, which paradoxically can create a histamine response if applied to the skin. This interesting phenomenon follows the herbal principle of ‘like cures like.’ When drunk as a tea or infusion or taken as a tincture, Stinging nettle is a supremely helpful and bioavailable nutrition powerhouse that helps to calm allergic responses, increase flow in the lymphatic system, and remineralize and replenish the inflamed body.